Thursday, August 11, 2011

Intelligent Research?

While the movie Captain America raises issues about human experimentation, the reimagined Rise of the Planet of the Apes (2011) deals with gene therapy. The underlying question that should be addressed is whether that  human beings be allowed to meddle with their own genetic code? While the genetic code is not related to consciousness and perhoodhood, it does in some ways related foundationally to who human beings are physically. In one sense, we are our God given (via or parents) genetic code. Do we then have a right to alter our own genetic code? This question cannot be answered unless we have a comprehensive theology of the body and a deeper understanding of Christian anthropology.

A brief movie synopsis from Wiki (contains spoilers)
Will Rodman (James Franco) is a San Francisco scientist at GEN-SYS who has been trying to develop a cure for Alzheimer's disease by testing a genetically engineered retrovirus on chimpanzees. The virus mutates the chimpanzees, giving them a human level of intelligence. One of his test subjects, a female chimpanzee named Bright Eyes, goes on a rampage because she believes her baby, to whom she secretly gave birth, is threatened. She is killed after disrupting a board meeting. Will's boss Steven Jacobs (David Oyelowo) orders subordinate Robert Franklin (Tyler Labine) to put all the test chimpanzees down, but he cannot bring himself to kill the chimpanzee's baby, and instead gives him to Will, who names him Caesar (Andy Serkis) and raises him in his house.Caesar has inherited his mother's high intelligence, and learns quickly.

Three years later, Will gives a sample of his cure to his father, Charles (John Lithgow), who is suffering from Alzheimer's disease. At first, his father improves but, five years later, his body's immune system fights off the virus and his dementia more.

The first issue on scientific research raised in this movie is the scientific safety protocols. While using a retrovirus to introduce a new gene into another species is a proven method of gene insertion, delivering it by aerosol (air borne) is not safe. Maybe it is good for storytelling as in the movies but in the scientific world, it is a dangerous delivery system. It is not easily controlled and may spread to the general population. Experiments involving viruses, especially those for gene insertion must be conducted in high secured and controlled environments. There are two potentially dangerous scenarios. If the virus (usually a retrovirus) gets to the general population, it may affect the certain people. It may not be so dramatic as in the movie. Some people may die because of the effect. The second scenarios is that the retrovirus infect the germline cells like the ovum and spermatozoa. In this scenarios, the introduced gene may be transmitted to the next generation. The reason I raise this issue is that we are at the beginning of a molecular biological revolution in the field of science and genetics. Everyone wants to be part of the revolution. Genetic laboratories are being set up all over the world. Are there adequate safeguards in all of these laboratories? Will there be backlane genetic labs as in the movie Blade Runner(my review here)

Secondly regards the consequences of genetic manipulation. In this movie, it is implied that in there will be sequels and in these sequels, intelligent apes will take over the world while humans will become intellectually challenged. The chimpanzee Caesar showed the pain and isolation of an intelligent chimpanzee in a world where chimpanzees are dumb pets.  In genetic manipulation as in chimera research, scientists are bringing into beings, creatures that never previous existed. Chimera research involve mixing human and animal genetic materials. Chimera research needs to be strictly supervised. Or will genetic manipulation create a Khan Noonien Singh which cause so much havoc in the Star Trek Universe?

Thirdly, the way the scientist Will Rodman stole samples of the experimental virus and inject it directly into his father who has Azheimer is a horrifying example of how human trials can go wrong. The methodology is important for all experiments. There is a reason why FDA has strict protocols for all drug trials. Scientific experiments need to be objective and impartial unlike a Frankenstein movie.

It is interesting how this movie makes the point that research in intelligence must also be intelligent research.


Labels: ,


Blogger kc bob said...

Don't know much about this or have anything intelligent to share but I do wonder why we not fix something if we knew it to be broken.

I have Hereditary Hemochromatosis and would not have objected to having it fixed genetically.. if that was even possible.

Kansas Bob
Fighting Captcha since 2005

6:18 AM  
Blogger Alex Tang said...

I agree with you. I believe that if God do not want use to fix what is broken, He would not have provided the tools.

I am sorry about your condition but there is as yet no way to have it fixed genetically.

1:04 PM  
Blogger kc bob said...

So are you thinking that manipulating the genetic code would be a good thing if it resulted in preventing hereditary diseases like the one that I have?

Kansas Bob
Fighting Captcha since 2005

9:35 PM  
Blogger Alex Tang said...

Yes, Bob. IMHO, it will be a good thing if we can manipulate our genes to get rid of all inheritable diseases. We worship God not our genetic code.

11:00 PM  
Blogger kc bob said...

Loved that last sentence Alex!

Kansas Bob
Fighting Word Verification since 2005

11:03 PM  

Post a Comment

<< Home